This search combines search strings from the content search (i.e. "Full Text", "Author", "Title", "Abstract", or "Keywords") with "Article Type" and "Publication Date Range" using the AND operator.
Beilstein J. Org. Chem. 2024, 20, 912–920, doi:10.3762/bjoc.20.81
Graphical Abstract
Figure 1: Representative bioactive tetrazole- and tetrahydroisoquinoline-containing compounds.
Scheme 1: The Ugi and Ugi-azide reactions.
Scheme 2: Ugi-azide and post-condensation reactions for the synthesis of various heterocyclic scaffolds.
Scheme 3: One-pot synthesis of tetrazolyl-1,2,3,4-tetrahydroisoquinoline.
Scheme 4: One-pot synthesis of tetrazolo-pyrazino[2,1-a]isoquinolin-6(5H)-ones 6.
Scheme 5: One-pot synthesis for tetrazolyl-1,2,3,4-tetrahydroisoquinolines 8.
Scheme 6: Gram-scale two-step one-pot synthesis of 6c.
Figure 2: ORTEP diagrams of compound 6d (left) [CCDC: 2164364] and 8c (right) [CCDC: 2321622].
Beilstein J. Org. Chem. 2020, 16, 1225–1233, doi:10.3762/bjoc.16.106
Figure 1: Bioactive pyrrolo[2,1-a]isoquinolines and hexahydropyrrolo[2,1-a]isoquinolines.
Scheme 1: [3 + 2] Cycloaddition with amino esters or amino acids.
Scheme 2: Scaffolds derived from the initial [3 + 2] adducts.
Scheme 3: [3 + 2] Cycloaddition with amino esters or amino acids. Conditions: 1:3:4 (1.2:1:1.1), Et3N (1.5 eq...
Scheme 4: Synthesis of pyrrolo[2,1-a]isoquinolines 9. Reaction conditions: 5 (0.5 mmol, 1 equiv), 7 (3 equiv)...
Scheme 5: Synthesis of pyrrolo[2,1-a]isoquinolines 11. Reaction conditions: 6 (0.5 mmol, 1 equiv), 7 (3 equiv...
Scheme 6: Synthesis of pyrrolo[2,1-a]isoquinolines 12. Reaction conditions: 5 or 6 (0.5 mmol, 1 equiv), cinna...
Scheme 7: Plausible mechanism for the synthesis of 9a.